{"id":23324,"date":"2023-09-12T11:50:12","date_gmt":"2023-09-12T18:50:12","guid":{"rendered":"https:\/\/ameripharmaspecialty.com\/?p=23324"},"modified":"2026-03-24T09:23:41","modified_gmt":"2026-03-24T16:23:41","slug":"how-long-does-ivig-stay-in-your-system","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/es\/ivig\/how-long-does-ivig-stay-in-your-system\/","title":{"rendered":"\u00bfCu\u00e1nto tiempo permanece la IgIV en el sistema?"},"content":{"rendered":"\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/ivig\/\/ivig\/\">IVIG (Intravenous immunoglobulin)<\/a> can stay in your system for up to 3 to 5 months after the last dose. Nonetheless, this duration varies depending on several factors.&nbsp;<\/span><\/p>\n\n\n\n<div  id=\"call-to-action-993d42dd72fa2c160daed2b386aac59a\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tGet IVIG Prior Authorization\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<p><span style=\"font-weight: 400;\">This article explains how providers determine how long IVIG stays in your system, and it answers the top 3 common questions about IVIG therapy.&nbsp;<\/span><\/p>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/how-long-does-ivig-stay-in-your-system\/#How_Long_IVIG_Stays_in_Your_System_Depends_on_the_Products_Half-Life\" >How Long IVIG Stays in Your System Depends on the Product\u2019s Half-Life<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/how-long-does-ivig-stay-in-your-system\/#Factors_Affecting_Half-life\" >Factors Affecting Half-life<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/how-long-does-ivig-stay-in-your-system\/#Condition_Being_Treated\" >Condition Being Treated<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/how-long-does-ivig-stay-in-your-system\/#Your_Dosing_Schedule\" >Your Dosing Schedule&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/how-long-does-ivig-stay-in-your-system\/#KidneyLiver_Disease\" >Kidney\/Liver Disease<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/how-long-does-ivig-stay-in-your-system\/#FAQs\" >FAQs<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_Long_IVIG_Stays_in_Your_System_Depends_on_the_Products_Half-Life\"><\/span>How Long IVIG Stays in Your System Depends on the Product\u2019s Half-Life<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Half-life, also called elimination half-life, is the time it takes to remove 50% of the drug concentration from the body. Simply put, after one half-life, your body has only half of the initial dose you received.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">A drug is considered to be completely eliminated after 4 to 5 half-lives [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554498\/#\"><span style=\"font-weight: 400;\">1<\/span><\/a><span style=\"font-weight: 400;\">]. So, if a drug has a half-life of 5 days, it is no longer present in your system after 20 to 25 days.\u00a0<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">The half-life of a typical IVIG infusion ranges from 3 to 4 weeks [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554446\/\"><span style=\"font-weight: 400;\">2].<\/span><\/a><span style=\"font-weight: 400;\"> Thus, your body will likely get rid of all IVIG 3 to 5 months after the last dose.\u00a0<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Because there are significant differences in the half-lives of <a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/ivig\/\/ivig-brand-reviews\/\">different IVIG products<\/a>, the maximum time for clearance can vary widely.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">The following table lists commonly used products and their average half-lives.&nbsp;<\/span><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><b>Product<\/b><\/td><td><b>Half-life (days)<\/b><\/td><\/tr><tr><td><span style=\"font-weight: 400;\">Octagam<\/span><\/td><td><span style=\"font-weight: 400;\">40<\/span><\/td><\/tr><tr><td><span style=\"font-weight: 400;\">Flebogamma<\/span><\/td><td><span style=\"font-weight: 400;\">37<\/span><\/td><\/tr><tr><td><span style=\"font-weight: 400;\">Gammaplex<\/span><\/td><td><span style=\"font-weight: 400;\">6<\/span><\/td><\/tr><tr><td><span style=\"font-weight: 400;\">Gamunex<\/span><\/td><td><span style=\"font-weight: 400;\">35&nbsp;<\/span><\/td><\/tr><tr><td><span style=\"font-weight: 400;\">Bivigam<\/span><\/td><td><span style=\"font-weight: 400;\">33&nbsp;<\/span><\/td><\/tr><tr><td><span style=\"font-weight: 400;\">Gammaked&nbsp;<\/span><\/td><td><span style=\"font-weight: 400;\">35<\/span><\/td><\/tr><tr><td><span style=\"font-weight: 400;\">Privigen<\/span><\/td><td><span style=\"font-weight: 400;\">45<\/span><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><span style=\"font-weight: 400; font-size: 12px;\">Source: <a href=\"https:\/\/www.hhs.texas.gov\/sites\/default\/files\/documents\/apr-2022-durb-agenda-item5w.pdf\">Immune Globulins Therapeutic Class Review (TCR) 2021<\/a><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Factors_Affecting_Half-life\"><\/span>Factors Affecting Half-life<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Condition_Being_Treated\"><\/span><span style=\"font-weight: 400;\">Condition Being Treated<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">The condition for which you are receiving immunoglobulin therapy can affect the half-life.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">For example, Gamimune at the same dose (0.5g\/kg) has two different half-lives. In patients with primary immunodeficiency, the half-life is approximately 14 days. On the other hand, it is 20 days in those with secondary immunodeficiency diseases [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4808809\/\"><span style=\"font-weight: 400;\">3<\/span><\/a>].<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Your_Dosing_Schedule\"><\/span><span style=\"font-weight: 400;\">Your Dosing Schedule&nbsp;<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Half-life can vary according to your dosing schedule as well.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">For instance, the half-life of Flebogamma 5% is 30 days for patients on a 3-week schedule, while it is 32 days for those on a 4-week schedule [<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=2cf22c72-64ac-45be-b7c6-d20340730096\"><span style=\"font-weight: 400;\">4<\/span><\/a>].<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"KidneyLiver_Disease\"><\/span><span style=\"font-weight: 400;\">Kidney\/Liver Disease<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Kidney disease reduces drug excretion. It can cause the drug to stay in your system for a longer period. Likewise, liver disorders affect how your body processes a drug.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">If you have kidney\/liver disease, your doctor may adjust the dosage to reduce the risk of toxicity.&nbsp;<\/span><\/p>\n\n\n\n<div  id=\"call-to-action-09f9c8ea464f622c785510d43187096d\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tGet IVIG Copay Assistance\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"cta__sub__heading\">\n\t\t\t\t\t\t\tIVIG Financial Assistance\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"#form\">Consult an IVIG Specialist<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"FAQs\"><\/span>FAQs<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h4 class=\"wp-block-heading\"><span style=\"font-weight: 400;\">Does IVIG Work Immediately?<\/span><\/h4>\n\n\n\n<p><span style=\"font-weight: 400;\">No, it does not work immediately. IVIG therapy works best when it is continued for several months and even years. IVIG therapy is like running a marathon; it is not a race. Patients will have different responses to treatment, and therefore, it is best to continue treatment over time in order to see results.&nbsp;<\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span style=\"font-weight: 400;\">How Long Does It Take for IVIG To Wear Off?<\/span><\/h4>\n\n\n\n<p><span style=\"font-weight: 400;\">The \u201cwear-off\u201d effect usually kicks in towards the final days of the 3- or 4-week schedule. This period is characterized by malaise, fatigue, a higher risk of infection, and joint\/muscle pain. However, when therapy is continued, most patients do not experience the wear-off period.<\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span style=\"font-weight: 400;\">Does IVIG Cause Weight Gain?<\/span><\/h4>\n\n\n\n<p><span style=\"font-weight: 400;\">IVIG therapy is unlikely to cause weight gain in most patients. However, unexpected weight gain during therapy could indicate kidney problems. Talk to your provider immediately if this happens.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>La inmunoglobulina intravenosa (IVIG) puede permanecer en el organismo hasta de 3 a 5 meses despu\u00e9s de la \u00faltima dosis. Sin embargo, esta duraci\u00f3n var\u00eda seg\u00fan varios factores. Este art\u00edculo explica c\u00f3mo los profesionales sanitarios determinan cu\u00e1nto tiempo permanece la IGIV en el organismo y responde a las tres preguntas m\u00e1s frecuentes sobre la terapia con IGIV.\u00a0<\/p>","protected":false},"author":13,"featured_media":23326,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[7],"tags":[17],"class_list":["post-23324","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ivig","tag-dr-saba-rassouli"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>How Long Does IVIG Stay in Your System? | AmeriPharma<\/title>\n<meta name=\"description\" content=\"Find out how long IVIG stays in your system and how long the effects last. 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