{"id":22640,"date":"2023-04-25T09:59:51","date_gmt":"2023-04-25T16:59:51","guid":{"rendered":"https:\/\/ameripharmaspecialty.com\/?p=22640"},"modified":"2026-03-24T09:58:22","modified_gmt":"2026-03-24T16:58:22","slug":"a-guide-to-ruxience-rituximab-how-it-works-dosing-and-side-effects","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/es\/other-health-conditions\/a-guide-to-ruxience-rituximab-how-it-works-dosing-and-side-effects\/","title":{"rendered":"Gu\u00eda sobre Ruxience (Rituximab): C\u00f3mo funciona, dosis y efectos secundarios"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Ruxience, el nombre comercial de rituximab, se utiliza para tratar a adultos con leucemia linfoc\u00edtica cr\u00f3nica (LLC), granulomatosis con poliange\u00edtis (GPA) (granulomatosis de Wegener), poliange\u00edtis microsc\u00f3pica (MPA), <a href=\"https:\/\/ameripharmaspecialty.com\/es\/other-health-conditions\/an-overview-of-rheumatoid-arthritis\/\">artritis reumatoide<\/a> (AR) y ciertos tipos de linfoma no Hodgkin (LNH).<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">El Ruxience es un anticuerpo monoclonal que forma parte de un grupo de medicamentos llamados biosimilares. Interact\u00faa con una prote\u00edna llamada <a href=\"https:\/\/www.cancer.gov\/publications\/dictionaries\/cancer-terms\/def\/cd20\">CD20<\/a> que est\u00e1 presente en los linfocitos B, un tipo de gl\u00f3bulo blanco. Se cree que act\u00faa solo para destruir las c\u00e9lulas cancerosas o ayuda al sistema inmunitario a eliminarlas.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Ruxience es una formulaci\u00f3n intravenosa (IV) est\u00e9ril, libre de conservantes, transparente a ligeramente opalescente e incolora a amarillo parduzco p\u00e1lido. Hay viales de dosis \u00fanica de Ruxience de 100 mg\/10 ml o 500 mg\/50 ml, ambos con una concentraci\u00f3n de 10 mg\/ml.<\/span><\/p>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Alternar tabla de contenido\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Palanca<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/es\/other-health-conditions\/a-guide-to-ruxience-rituximab-how-it-works-dosing-and-side-effects\/#What_Is_Ruxience_Used_For\" >\u00bfPara qu\u00e9 se utiliza el Ruxience?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/es\/other-health-conditions\/a-guide-to-ruxience-rituximab-how-it-works-dosing-and-side-effects\/#How_It_Works\" >C\u00f3mo funciona<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/es\/other-health-conditions\/a-guide-to-ruxience-rituximab-how-it-works-dosing-and-side-effects\/#Precautions_Before_and_After_Using_Ruxience\" >Precauciones antes y despu\u00e9s de usar Ruxience<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/es\/other-health-conditions\/a-guide-to-ruxience-rituximab-how-it-works-dosing-and-side-effects\/#Drug_Dosage_and_Administration\" >Dosis y administraci\u00f3n de medicamentos<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/es\/other-health-conditions\/a-guide-to-ruxience-rituximab-how-it-works-dosing-and-side-effects\/#Side_Effects\" >Efectos secundarios<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/es\/other-health-conditions\/a-guide-to-ruxience-rituximab-how-it-works-dosing-and-side-effects\/#Cost\" >Costo<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_Is_Ruxience_Used_For\"><\/span>\u00bfPara qu\u00e9 se utiliza el Ruxience?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Ruxience se utiliza en el tratamiento de c\u00e1nceres como el LNH y la LCC solo o en combinaci\u00f3n con otros <a href=\"https:\/\/ameripharmaspecialty.com\/es\/cancer\/what-is-tafinlar-dabrafenib\/\">agentes de quimioterapia<\/a>. Funciona reduciendo o deteniendo el desarrollo de c\u00e9lulas cancerosas.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Ruxience tambi\u00e9n se utiliza para tratar la AR de moderada a grave en combinaci\u00f3n con metotrexato en aquellos pacientes con una respuesta inadecuada a otras terapias de tratamiento. Ruxience ayuda a reducir las molestias y la hinchaz\u00f3n de las articulaciones.&nbsp;<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">El Ruxience act\u00faa en el MPA y el GPA para prevenir la acci\u00f3n de los componentes del sistema inmunitario sobre s\u00ed mismo. Esto puede disminuir la inflamaci\u00f3n de los vasos sangu\u00edneos (vasculitis) y ayudar a prevenir el da\u00f1o org\u00e1nico. El Ruxience se utiliza en combinaci\u00f3n con un grupo de esteroides llamados glucocorticoides para esta indicaci\u00f3n.<\/span><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_It_Works\"><\/span>C\u00f3mo funciona<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Como anticuerpo monoclonal, el Ruxience se une selectivamente al ant\u00edgeno transmembrana CD20 presente en los linfocitos B y pre-B maduros. Una vez unido al CD20, se cree que marcar\u00e1 las c\u00e9lulas para su destrucci\u00f3n o informar\u00e1 al sistema inmunitario que pueden ser destruidas.&nbsp;<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Precautions_Before_and_After_Using_Ruxience\"><\/span>Precauciones antes y despu\u00e9s de usar Ruxience<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Ruxience solo debe utilizarse en entornos con acceso r\u00e1pido a recursos de reanimaci\u00f3n completos y bajo la estricta supervisi\u00f3n de un profesional sanitario calificado.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Antes de comenzar cada infusi\u00f3n de Ruxience, se administrar\u00e1 premedicaci\u00f3n con un analg\u00e9sico\/antipir\u00e9tico (como acetaminof\u00e9n) y un antihistam\u00ednico (como difenhidramina) para reducir el riesgo de reacci\u00f3n a la infusi\u00f3n. La primera infusi\u00f3n puede durar de 4 a 6 horas; sin embargo, las infusiones posteriores deber\u00edan durar entre 3 y 4 horas.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">El Ruxience puede interactuar con otros medicamentos. Por lo tanto, debe informar a su m\u00e9dico sobre todos los medicamentos o suplementos que est\u00e9 tomando, ya sean con receta, vitaminas, medicamentos de venta libre o suplementos herbales.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Aseg\u00farese de discutir su historial m\u00e9dico con su m\u00e9dico, ya que este medicamento puede empeorar ciertas afecciones, especialmente si tiene problemas card\u00edacos o renales, un sistema inmunol\u00f3gico debilitado o el virus de la hepatitis B.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Drug_Dosage_and_Administration\"><\/span>Dosis y administraci\u00f3n de medicamentos<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Solo profesionales m\u00e9dicos con los recursos necesarios deben administrar Ruxience, y cada infusi\u00f3n debe ir precedida de premedicaci\u00f3n para prevenir reacciones graves relacionadas con la infusi\u00f3n que podr\u00edan ser mortales. Su m\u00e9dico le realizar\u00e1 an\u00e1lisis de sangre peri\u00f3dicos para detectar cualquier efecto secundario y comprobar la eficacia del medicamento.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">La dosis de Ruxience var\u00eda seg\u00fan la indicaci\u00f3n y la superficie corporal.&nbsp;<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Para el LNH, la dosis recomendada es de 375 mg\/m\u00b2.<\/span><span style=\"font-weight: 400;\">. <\/span><span style=\"font-weight: 400;\">Su m\u00e9dico le proporcionar\u00e1 instrucciones espec\u00edficas sobre cu\u00e1ntas dosis recibir\u00e1 para el tratamiento y si se necesitan otros agentes de quimioterapia.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Para la LLC, se administrar\u00e1 una dosis de 375 mg\/m\u00b2 el primer d\u00eda del primer ciclo, seguida de una dosis de 500 mg\/m\u00b2 para las dosis subsiguientes. Completar\u00e1 seis ciclos de 28 d\u00edas con los medicamentos de quimioterapia fludarabina y <a href=\"https:\/\/ameripharmaspecialty.com\/es\/discontinued\/cyclophosphamide\/\">ciclofosfamida<\/a>.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">En la AR, el Ruxience se administra en combinaci\u00f3n con metotrexato en dos infusiones de 1000 mg con dos semanas de diferencia. Pueden ser necesarios ciclos posteriores seg\u00fan la respuesta al tratamiento, que deben administrarse cada 24 semanas.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Para la GPA y la MPA, la dosis inicial es de 375 mg\/m\u00b2 una vez a la semana durante 4 semanas. Para los pacientes que hayan logrado controlar la enfermedad despu\u00e9s del primer mes de tratamiento, su m\u00e9dico podr\u00eda recetar dos dosis adicionales de 500 mg\/m\u00b2 con un intervalo de 2 semanas, seguidas de una infusi\u00f3n de 500 mg cada 6 meses, seg\u00fan la respuesta al tratamiento.<\/span><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Side_Effects\"><\/span>Efectos secundarios<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright\"><img loading=\"lazy\" decoding=\"async\" width=\"420\" height=\"280\" src=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/04\/tired-woman.jpg\" alt=\"Tired woman suffering from Ruxience side effects\" class=\"wp-image-22642\" srcset=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/04\/tired-woman.jpg 420w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/04\/tired-woman-300x200.jpg 300w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/04\/tired-woman-330x220.jpg 330w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/04\/tired-woman-86x57.jpg 86w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/04\/tired-woman-167x111.jpg 167w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/04\/tired-woman-280x187.jpg 280w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/04\/tired-woman-370x247.jpg 370w\" sizes=\"auto, (max-width: 420px) 100vw, 420px\" \/><\/figure>\n<\/div>\n\n\n<p><span style=\"font-weight: 400;\">Las personas que toman este medicamento pueden experimentar reacciones leves o graves despu\u00e9s de la infusi\u00f3n. Por lo tanto, no dude en informar a su profesional de la salud sobre cualquier reacci\u00f3n que note durante o despu\u00e9s de una infusi\u00f3n. Ruxience no debe administrarse a personas con hepatitis B activa.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Los siguientes son algunos de los efectos secundarios m\u00e1s comunes del Ruxience:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Infecciones (especialmente infecciones de las v\u00edas respiratorias superiores)<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Fiebre<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Escalofr\u00edos<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Debilidad<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Cansancio<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">dolores corporales&nbsp;<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">N\u00e1useas<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Recuentos bajos de gl\u00f3bulos rojos y gl\u00f3bulos blancos&nbsp;&nbsp;<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Dolor de cabeza<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">espasmos musculares<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Hinchaz\u00f3n de las extremidades (edema)<\/span><\/li>\n<\/ul>\n\n\n\n<p><span style=\"font-weight: 400;\">Debido a la r\u00e1pida eliminaci\u00f3n de las c\u00e9lulas cancerosas, Ruxience puede ocasionalmente inducir <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3437249\/#:~:text=The%20tumor%20lysis%20syndrome%20occurs,hyperkalemia%2C%20hyperphosphatemia%2C%20and%20hypocalcemia.\">s\u00edndrome de lisis tumoral<\/a> Esto puede provocar insuficiencia renal y arritmias. Informe a su m\u00e9dico si presenta n\u00e1useas, v\u00f3mitos, diarrea o falta de energ\u00eda entre 12 y 24 horas despu\u00e9s de la infusi\u00f3n.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Pueden presentarse reacciones cut\u00e1neas graves en cualquier momento durante el tratamiento con Ruxience. Si experimenta llagas dolorosas, sarpullido, ampollas, descamaci\u00f3n de la piel o p\u00fastulas alrededor de los labios o la boca, notifique de inmediato a su profesional de la salud.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/rarediseases.org\/rare-diseases\/progressive-multifocal-leukoencephalopathy\/\">Leucoencefalopat\u00eda multifocal progresiva<\/a> La leucoencefalopat\u00eda multifocal progresiva (LMP) es una infecci\u00f3n cerebral poco frecuente que puede presentarse en pacientes que toman Ruxience. Informe a su m\u00e9dico de inmediato si experimenta problemas de visi\u00f3n, p\u00e9rdida del equilibrio, dificultad para caminar o hablar, o debilidad en un lado del cuerpo.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Tambi\u00e9n debe informar a su m\u00e9dico de inmediato si experimenta alguno de los siguientes s\u00edntomas durante o despu\u00e9s de la infusi\u00f3n, ya que podr\u00eda estar experimentando una reacci\u00f3n a la infusi\u00f3n:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Urticaria<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Dificultad para respirar<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Hinchaz\u00f3n de la cara, labios, lengua o garganta.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Picor<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Mareo<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Dificultad para respirar<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Dolor o presi\u00f3n en el pecho<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">sibilancias<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Tos repentina<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Latidos card\u00edacos acelerados<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Enrojecimiento, calor o hinchaz\u00f3n de la piel.<\/span><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Cost\"><\/span>Costo<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Dependiendo de la farmacia, el precio al por mayor de una dosis de Ruxience es de aproximadamente $764 por un suministro de 10 ml. La cantidad exacta que paga por el medicamento depende de varios factores, como su ubicaci\u00f3n y su plan de salud.<\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>Ruxience, el nombre comercial de rituximab, se utiliza para tratar a adultos con leucemia linfoc\u00edtica cr\u00f3nica (LLC), granulomatosis con poliange\u00edtis (GPA) (granulomatosis de Wegener), poliange\u00edtis microsc\u00f3pica (PAM), artritis reumatoide (AR) y ciertos tipos de linfoma no Hodgkin (LNH).<\/p>","protected":false},"author":27,"featured_media":22641,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[4],"tags":[33],"class_list":["post-22640","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-other-health-conditions","tag-dr-samantha-kaeberlein"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A Guide to Ruxience (Rituximab): How It Works, Dosing, and Side Effects<\/title>\n<meta name=\"description\" content=\"Learn about the drug Ruxience (rituximab). Topics covered include how the drug works, cost, precautions, dosing and side effects.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ameripharmaspecialty.com\/es\/other-health-conditions\/a-guide-to-ruxience-rituximab-how-it-works-dosing-and-side-effects\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Guide to Ruxience (Rituximab): How It Works, Dosing, and Side Effects\" \/>\n<meta property=\"og:description\" content=\"Learn about the drug Ruxience (rituximab). 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