Ocrevus Dosing Information

Ocrevus is available as a 300 mg/10 ml (30 mg/ml) single-dose vial.

Ocrevus is initially dosed as 300 mg intravenously followed by a 300 mg intravenous infusion after 2 weeks. After the initial infusions, the Ocrevus dosage will be increased to 600 mg, and it will be infused every 6 months. Ocrevus is only dosed twice per year after the initial doses which makes it a convenient option for patients and prescribers.

Ocrevus should be infused under close monitoring in a medical office due to the potential risk of infusion reactions and the need to access medical supplies and personnel. Patients should be premedicated before each infusion. It is recommended to pre-medicate with 100 mg of methylprednisolone (or an equivalent dose of corticosteroid), and an antihistamine such as diphenhydramine at least 30 – 60 minutes before the infusion in order to reduce the possibility of infusion reactions.

Some patients can also be prescribed acetaminophen (Tylenol) before each infusion to decrease the chance of fever.

If an infusion is missed, it should be rescheduled as soon as possible, and the patient’s schedule should be reset to every 6 months from the last infused dose. Patients should be screened for hepatitis B virus, serum Immunoglobulins, and vaccinations before starting therapy. Ocrevus is contraindicated in patients with active hepatitis B or a history of life-threatening infusion reactions.