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የታካሚያችንን ልዩ መድሃኒት ቤት ልምድ በማይዛመድ የሙሉ አገልግሎት ምቾት ማቀላጠፍ

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    1. የሽፋን/የጥቅማ ጥቅሞች ማረጋገጫዎን ያረጋግጡ

    የእኛ የባለሙያዎች የሂሳብ አከፋፋዮች ቡድን ከኪስ ወጪዎች የሚቀንሱትን ምርጥ የሽፋን መንገዶችን ያገኛል።

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    ከቀድሞው ፋርማሲዎ ወይም ከሐኪምዎ ጋር በመስራት ማዘዙን እናሰራለን፣ ይህም ሽግግሩን ፈጣን እና ቀላል ያደርገዋል።

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    3. የቅድሚያ ፍቃድ

    የእኛ የስፔሻሊስቶች ቡድን ከ24 እስከ 72 ሰአታት ውስጥ ከኢንሹራንስ ኩባንያዎችዎ ፈቃድ ያገኛል።

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    የገንዘብ ዕርዳታን እናስከብራለን እና የጋራ ክፍያን፣ ከኪስ ውጪ ወጪዎችን እና ከፍተኛ ተቀናሾችን እንቀንሳለን። እስካሁን፣ AmeriPharma® ስፔሻላይቲ ኬር $55 ሚሊዮን ለታካሚዎቻችን የገንዘብ ድጋፍ አግኝቷል።

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    መድሃኒቶች ሁልጊዜ የሚቀርቡት ለማጓጓዣ ልዩ መስፈርቶች በጥብቅ በማክበር ነው. በሚቀጥለው ቀን እና በሌሊት የቀዝቃዛ ሰንሰለት ማቅረቢያዎች በጊዜ ሰሌዳዎ ዙሪያ የተቀናጁ ናቸው።

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What Is Mekinist?

Mekinist is a medication used to treat several types of cancer in patients who have one of two specific gene mutations that are called BRAF V600E and BRAF V600K. Mekinist works by inhibiting the MEK1 and MEK2 kinase enzymes’ activity. These enzymes normally promote the cells’ rapid reproduction. Mekinist also activates the BRAF pathway, which inhibits melanoma cell growth.

The generic name of Mekinist is trametinib. It is manufactured by Novartis and was first approved by the ኤፍዲኤ in 2013.

Mekinist is currently only available as a brand-name medication, and it comes in oral tablets of 0.5 mg and 2 mg.

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What is Mekinist Used For?

Mekinist is FDA approved for the treatment of several cancer types when patients have BRAF V600E or BRAF V600K mutations (the mutations have to be detected by an approved test for Mekinist treatment to be appropriate). Mekinist is used as follows:

  • As a single agent: For the treatment of melanoma that cannot be surgically removed or that is metastatic. Mekinist should be used in patients with BRAF V600E or BRAF V600K mutations who have not been treated by a BRAF inhibitor before.
  • In combination with Tafinlar (dabrafenib) for:
    • Melanoma
      • As an adjuvant treatment in patients with BRAF V600E or BRAF V600K mutations and lymph node involvement following complete surgical removal of the melanoma.
      • For the treatment of melanoma that cannot be surgically removed or that is metastatic in patients with BRAF V600E mutation.
    • Metastatic non-small cell lung cancer in patients with BRAF V600E or BRAF V600K mutations.
    • Solid tumors that cannot be surgically removed or are metastatic in adult or pediatric patients (at least 6 years old) with BRAF V600E mutation whose tumors have progressed following prior treatment and who have no satisfactory alternative treatment options.
    • Anaplastic thyroid cancer that is locally advanced or metastatic in patients with BRAF V600E mutation that have no satisfactory treatment options.

Mekinist is NOT indicated for the treatment of colorectal cancer as it is known to have a resistance to BRAF inhibition.

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    የላቀ ሶፍትዌር እርስዎን ከከፍተኛ-ዶላር ፋውንዴሽን ፕሮግራሞች ጋር ለማዛመድ የገንዘብ ምንጮችን ያገኛል

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    በገንዘቡ ሁኔታ ላይ አውቶማቲክ ማሻሻያ ለእርስዎ እና ለሐኪምዎ ይላካል

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How To Take Mekinist

Upon confirmation of BRAF V600E or BRAF V600K mutations, Mekinist is taken as follows (please refer to the indicated use mentioned above for a full diagnosis description):

  • Melanoma (as a single agent or in combination with Tafinlar): 2 mg once daily.
  • Metastatic non-small cell lung cancer (in combination with Tafinlar): 2 mg once daily.
  • Solid tumors that cannot be surgically removed or that are metastatic (in combination with Tafinlar): 2 mg once daily.
  • Anaplastic thyroid cancer that is locally advanced or metastatic (in combination with Tafinlar): 2 mg once daily.

Mekinist should be taken at least 1 hour before or 2 hours after a meal. Doses should be taken about 24 hours apart, whether taken as a single agent or in combination with Tafinlar.

Missed doses should NOT be taken within 12 hours of the next dose.

If taken as a combination with Tafinlar, Mekinist should either be taken with the morning or evening dose of Tafinlar.

Mekinist Side Effects

 

  • Edema/swelling (including peripheral edema to the limbs)
  • High blood pressure (or worsening of existing high blood pressure)
  • Outbreak of acne-like papules and pustules
  • ሽፍታ
  • Skin dryness
  • Decrease in the serum albumin
  • የሆድ ህመም
  • ተቅማጥ
  • የአፍ ቁስሎች
  • Anemia
  • Bleeding
  • Lymphedema (tissue swelling due to accumulation of protein-rich fluid)
  • Increase in liver enzymes (ALT, ALP, and AST)
  • Slow heart rate
  • Bacterial skin infection
  • Inflammation of hair follicles
  • Infection around the nail
  • ማሳከክ
  • Altered taste
  • Dry mouth
  • መፍዘዝ
  • Muscle breakdown (can be damaging to the kidneys)
  • የደበዘዘ እይታ
  • Dry eyes
  • Interstitial lung disease
  • Inflammation of lung tissue

Mekinist may also cause: Bleeding problems, inflammation or tears to the stomach or intestines, blood clots, heart problems, eye problems, lung or breathing problems, fever, serious skin reactions, and increased blood sugar.

These are not all of the possible side effects that may occur. If you have questions about side effects, call your doctor.

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